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ADRB1基因编码功能及结构描述

2022.8.08
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zhaoqisun

致力于为分析测试行业奉献终身

肾上腺素能受体(α1、α2、β1和β2亚型)是鸟嘌呤核苷酸结合调节蛋白偶联受体的一个原型家族,介导肾上腺素和神经递质去甲肾上腺素的生理效应。β1肾上腺素受体主要位于心脏。该基因的特异性多态性已被证明影响静息心率,并可能与心力衰竭有关。[由RefSeq提供,2019年9月]

The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Beta-1 adrenoceptors are predominately located in the heart. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Sep 2019]

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