这个基因编码一种细胞表面蛋白，它是免疫球蛋白超家族的成员。该编码蛋白由4个N端免疫球蛋白样结构域、6个纤维粘连蛋白Ⅲ型结构域、1个跨膜结构域和1个与肿瘤抑制候选基因DCC同源的C端内结构域组成该蛋白可能参与细胞生长、分化和细胞-细胞粘附这种基因的缺陷与某些癌症的细胞增殖有关。交替剪接导致多个转录变体。
This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
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