NUP85基因编码功能及结构描述

该基因编码核孔复合物的Nup107-160亚单位的蛋白质成分核孔复合体嵌入核膜，促进大分子在细胞质和细胞核之间的双向运输。编码的蛋白质也可结合趋化因子（C-C基序）受体2（CCR2）的C端，并促进单核细胞趋化，从而参与炎症反应。选择性剪接导致多个转录变体.

This gene encodes a protein component of the Nup107-160 subunit of the nuclear pore complex. Nuclear pore complexes are embedded in the nuclear envelope and promote bidirectional transport of macromolecules between the cytoplasm and nucleus. The encoded protein can also bind to the C-terminus of chemokine (C-C motif) receptor 2 (CCR2) and promote chemotaxis of monocytes, thereby participating in the inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]