PAX7基因编码的功能和结构描述

该基因是PAX家族转录因子的一个成员这个基因家族的成员通常包含一个配对盒结构域、一个八肽和一个配对型同源结构域这些基因在胎儿发育和癌症生长过程中起着关键作用。配对框7基因的特异功能尚不清楚，但推测可能与肿瘤抑制有关，因为该基因与叉头结构域家族成员的融合与肺泡状横纹肌肉瘤有关已经发现了三个编码不同亚型的转录变体。

This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene.