RPS6KA1基因编码的功能和结构描述

该基因编码丝氨酸/苏氨酸激酶rsk（核糖体s6激酶）家族的一个成员。该激酶包含2个不同的激酶催化结构域并磷酸化各种底物，包括丝裂原活化激酶（MAPK）信号通路的成员这种蛋白的活性与控制细胞的生长和分化有关。交替转录剪接变体，编码不同的亚型，已经被描述出来。

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.