SLC22A3基因编码的功能和结构描述

在肝脏、肾脏、肠道和其他器官中的多特异性有机阳离子转运蛋白对于消除许多内源性小有机阳离子以及广泛的药物和环境毒素是至关重要的。这个基因是位于6号染色体上一个簇的三个相似的阳离子转运基因之一编码的蛋白质包含12个假定的跨膜结构域，是一种质膜完整蛋白。

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein.