Eukaryotic protein translation

The scanning translation initiation model suggests that 40S ribosomal subunit preloaded with factors bind to the 5’ end of the mRNA near the cap. The 48S subunit moves along the mRNA until it finds the initiation triplet and in complex with tRNA and 60S subunit formed the first peptide bond. Translation control is mostly regulated at the protein initiation step through translation initiation factors such as eIF2 or eIF4.

Contributor: Cell Signaling

REFERENCES: Dever T.E. (1999) Translation initiation: adept at adapting. Trends Biochem. Sci. 24, 398-403. Gingras AC et al. (1999) eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu. Rev. Biochem. 68, 913-963. Gray, N.K. and Wickens, M. (1998) Control of translation initiation in animals. Annu. Rev. Cell Dev. Biol. 14, 399-458. Palfrey, H.C. and Nairn, A.C. (1995) Calcium-dependent regulation of protein synthesis. Adv. Second Messenger Phosphoprotein Res. 30, 191-223. Rhoads, R.E. (1999) Signal transduction pathways that regulate eukaryotic protein synthesis. J. Biol. Chem. 274, 30337-30340.