目前随着微流控技术在生物学的应用，利用微流控技术和 3D 培养技术，能构建出细胞培养的微环境及活组织培养所需的机械结构和微环境，并能实现药物的梯度浓度变化。利用这些技术能够实现类似于正常器官组成的微型器官结构，这种方法或结构称为“芯片上的器官”（organs-on-chips）或“类器官”。
类器官模型是一种 3D（三维）细胞培养系统，其与体内的来源组织或器官高度相似。这些 3D 系统可复制出已分化组织的复杂空间形态，并能够表现出细胞与细胞以及细胞与基质之间的相互作用。
理想状态下，类器官与体内分化的组织具有相似的生理反应。这不同于传统的 2D（二维）细胞培养模型，后者在物理、分子和生理学等特性上通常与来源组织的相似性很低。
Molecular Devices 开启本次网络讲堂，与您一同探讨，3D 药筛新技术——类器官芯片。
网络讲堂信息
讲座时间：
2019 年 11 月 21 日 周四 14:00-16:00
报名链接：
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课程描述：
主题一：
从 2D 到 3D，高内涵药物筛选技术简谈
摘要：随着仪器制造技术，生物检测手段和计算机数据分析软件的不断革新。旨在以检测和分析多靶点多指标，更好的对化合物活性进行综合评价的高内涵药物筛选技术应运而生。在保持细胞结构和功能完整性的前提下，同时检测被筛选物对细胞形态、生长、分化、迁移、凋亡、代谢途径及信号转导等各项指标。
而由此，2D 细胞培养技术被大量应用在药物筛选、开发和疾病治疗的研究中。但是这种模型无法准确描述和模拟细胞在体内复杂的微环境和各种复杂生物学过程。因此，细胞球、类器官芯片等 3D 细胞培养技术不断更新，以研究细胞迁移、黏附和对药物反应的准确描述。
主讲人：朱文通
主题二：
Modeling gut and vasculature in the OrganoPlate - a high throughput microfluidic tissue culture platform.
摘要：The transition from 2D to 3D cell culture is a first step towards more physiologically relevant in vitro models for human (disease) modeling. To adequately capture the complex tissue architectures observed in vivo, 3D microfluidic techniques incorporate and achieve long-term gradient stability, continuous perfusion and patterning of cell layers as stratified co-cultures.
Mimetas develops Organ-on-a-Chip-based models for disease modeling and evaluation of new medicines. Our unique microfluidic technology – the OrganoPlate? – enables testing of compounds on miniaturized 3D organ models in high-throughput. These models are expected to show better physiological relevance versus conventional 2D cell culture models, without compromising throughput or ease of use. Combining these models with advanced and powerful imaging techniques really opens up a whole new panel of assays that researchers can use to get concrete answers to their questions very, very quickly and in a robust and scalable manner. This presentation provides an overview of the technology and its applications for gut and vasculature modeling.
主讲人：Linda Gijzen, MSc.
主讲人简介：
朱文通：美谷分子仪器（上海）有限公司，高级应用科学家 研究生毕业于华东理工大学药学院。在医药企业和显微成像领域工作多年，目前主要负责 Molecular Devices 公司高内涵产品线的技术与应用工作。熟悉药物筛选中的高通量成像技术及分析。
Linda Gijzen, MSc. : Linda is a Scientist in the Model Development team at Mimetas where she is working predominantly on the development and characterization of kidney-on-a-chip models. Besides that, she also worked on 3D intestinal and cancer on-a-chip models. She received her master’s degree in Biomedical Sciences at the Radboud University in Nijmegen (The Netherlands). Her main interest during the bachelor’s degree was Toxicology, where she gained research experience at the Radboud Institute for Molecular Life Science (RIMLS). During her master’s she further extended her knowledge and experience in Toxicology and Human Pathobiology. She investigated the effect of compounds on inducing hypoxia in mesenchymal stem cells and thereby stimulating angiogenesis in endothelial cells for purposes such as wound healing and tissue regeneration. At Mimetas she developed 3D proximal tubule on-a-chip models for high-throughput nephrotoxicity assessment and transporter interaction.
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