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在非靶向代谢检测技术的洪流中,广泛靶向代谢组凭借精准的定性定量能力和稳定的检测结果脱颖而出，获得了越来越多的专家及学者的认可。
小迈仅统计了近两年来通过使用广泛靶向代谢组产品进行代谢检测后发表在医学及动物领域的文章，发现影响因子已累计达239.674分，平均影响因子近8分。
据不完全统计，除去已发表的，还有近百余篇的项目文章正在撰写或投稿中。为方便各位老师对于文章中方法学部分内容进行引用，现将已发表的广泛靶向代谢组文章进行汇总，并附上原文链接（文末可一键下载）：
Publications citing Metware’s Widely-targeted Metabolomics
2022
HuZ, Feng J, Song H, et al. Metabolicresponse of Mercenaria mercenaria under heat and hypoxia stress bywidely targeted metabolomic approach[J]. Science of The Total Environment, 2022, 809: 151172.
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https://sciencedirect.53yu.com/science/article/abs/pii/S0048969721062501
GuoC, Xu Y, Ma Y, et al. Individualand joint effects of trehalose and glutamate on diabetic retinopathy:a propensity score-matched case-control study[J]. Endocrine Connections, 2022, 1(aop).
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https://ec.bioscientifica.com/view/journals/ec/11/2/EC-21-0474.xml
LiG, Zhao H, Guo D, et al. Distinctmolecular impact patterns of abamectin on Apis mellifera ligusticaand Apis cerana cerana[J].Ecotoxicology and Environmental Safety, 2022, 232: 113242.
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https://sciencedirect.53yu.com/science/article/pii/S0147651322000823
HuZ, Feng J, Song H, et al. Metabolicresponse of Mercenaria mercenaria under heat and hypoxia stress bywidely targeted metabolomic approach[J]. Science of The Total Environment, 2022, 809: 151172.
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https://sciencedirect.53yu.com/science/article/abs/pii/S0048969721062501
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2021
JingY, Luo L, Chen Y, et al. SARS-CoV-2infection causes immunodeficiency in recovered patients bydownregulating CD19 expression in B cells via enhancing B-cellmetabolism[J].Signal transduction and targeted therapy, 2021, 6(1): 1-13.
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https://www.nature.com/articles/s41392-021-00749-3
DingZ, Wang W, Zhang K, et al. Novelscheme for non-invasive gut bioinformation acquisition with amagnetically controlled sampling capsule endoscope[J]. Gut, 2021, 70(12): 2297-2306.
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https://gut.bmj.com/content/early/2021/10/07/gutjnl-2020-322465
WangC, Li X, Ning W, et al. Multi-omic profiling of plasma revealsmolecular alterations in children with COVID-19[J]. Theranostics,2021, 11(16): 8008.
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https://www.thno.org/v11p8008.htm
WangZ, Zhu Q, Liu Y, et al. Genome-wideassociation study of metabolites in patients with coronary arterydisease identified novel metabolite quantitative trait loci[J]. Clinical and translational medicine, 2021, 11(2).
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https://onlinelibrary.wiley.com/doi/10.1002/ctm2.290
XuJ, Zhou M, Luo P, et al. PlasmaMetabolomic Profiling of Patients Recovered From Coronavirus Disease2019(COVID-19) With Pulmonary Sequelae 3 Months After Discharge [J].Clinical Infectious Diseases, 2021, 73(12): 2228-2239.
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https://academic.oup.com/cid/article/73/12/2228/6141511?login=false
MaX, Xiao W, Li H, et al. Metforminrestores hippocampal neurogenesis and learning and memory viaregulating gut microbiota in the obese mouse model[J]. Brain, Behavior, and Immunity, 2021, 95: 68-83.
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https://www.sciencedirect.com/science/article/pii/S0889159121000532?via%3Dihub
TangY, Pan Y, Chen Y, et al. Metabolomicprofiling of aqueous humor and plasma in primary open angle glaucomapatients points towards novel diagnostic and therapeutic strategy[J]. Frontiers in pharmacology, 2021, 12.
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https://www.frontiersin.org/articles/10.3389/fphar.2021.621146/full
LiM, Haixia Y, Kang M, et al. TheArachidonic Acid Metabolism Mechanism Based on UPLC-MS/MSMetabolomics in Recurrent Spontaneous Abortion Rats [J].Frontiers in Endocrinology, 2021, 12: 291.
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https://www.frontiersin.org/articles/10.3389/fendo.2021.652807/full
ZhouM, Tan X, Luo P, et al. Changesin glomerular filtration rate and metabolomic differences in severelyill coronavirus disease survivors 3 months after discharge[J].Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 2022,1868(1): 166289.
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https://www.sciencedirect.com/science/article/pii/S0925443921002222?via%3Dihub
CaoP, Wu S, Guo W, et al. Precisepathological classification of non-small cell lung adenocarcinoma andsquamous carcinoma based on an integrated platform of targetedmetabolome and lipidome[J].Metabolomics, 2021, 17(11): 1-11.
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https://linkspringer.53yu.com/article/10.1007/s11306-021-01849-5
MengQ, Hu X, Zhao X, et al. Acircular network of coregulated sphingolipids dictates lung cancergrowth and progression[J]. EBioMedicine, 2021, 66: 103301.
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https://sciencedirect.53yu.com/science/article/pii/S2352396421000943
GuF, Liang S, Zhu S, et al. Multi-omicsrevealed the effects of rumen-protected methionine on the nutrientprofile of milk in dairy cows[J]. Food Research International, 2021, 149: 110682.
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https://sciencedirect.53yu.com/science/article/abs/pii/S0963996921005810
ZhangZ, Zhou C, Fan K, et al. Metabolomicsanalysis of the effects of temperature on the growth and developmentof juvenile European seabass (Dicentrarchus labrax)[J].Science of The Total Environment, 2021, 769: 145155.\\
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https://sciencedirect.53yu.com/science/article/abs/pii/S0048969721002217
HeL, Zhu D, Liang X, et al. Multi-omicssequencing provides insights into age-dependent susceptibility ofgrass carp (Ctenopharyngodon idellus) to reovirus[J].Frontiers in immunology, 2021, 12: 2396.
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247658/
ZhangH, Liu Y, Zhou L, et al. Metabonomicinsights into the sperm activation mechanisms in ricefield eel(Monopterus albus)[J].Genes, 2020, 11(11): 1259.
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https://www.mdpi.com/2073-4425/11/11/1259
GuF, Liang S, Zhu S, et al. Multi-omicsrevealed the effects of rumen-protected methionine on the nutrientprofile of milk in dairy cows[J]. Food Research International, 2021, 149: 110682.
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https://sciencedirect.53yu.com/science/article/abs/pii/S0963996921005810
YaoF, Wang X, Cao X, et al. Integrationof transcriptomics and metabolomics confirmed hepatoprotectiveeffects of steamed shoot extracts of ginseng (Panax ginseng CA Meyer)on toxicity caused by overdosed acetaminophen[J]. Biomedicine & Pharmacotherapy, 2021, 143: 112177.
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https://sciencedirect.53yu.com/science/article/pii/S0753332221009616
SongH, Wei L, Zhong M, et al. Ambientultraviolet B radiation induced valve behavioral acclimation ofPacific oyster which resulted from the different response strategiesof smooth and striated adductor muscles[J].Ecotoxicology and Environmental Safety, 2021, 228: 113035.
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https://sciencedirect.53yu.com/science/article/pii/S0147651321011477
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2020
WuD, Shu T, Yang X, et al. Plasmametabolomic and lipidomic alterations associated with COVID-19[J].National Science Review, 2020, 7(7): 1157-1168.
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https://academic.oup.com/nsr/article/7/7/1157/5826189?login=false
ZhaoY, Shang Y, Ren Y, et al. Omicsstudy reveals abnormal alterations of breastmilk proteins andmetabolites in puerperant women with COVID-19[J].Signal transduction and targeted therapy, 2020, 5(1): 1-3.
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https://sci-hub.se/10.1038/s41392-020-00362-w
ZhaoH, Li G, Guo D, et al. Transcriptomicand metabolomic landscape of the molecular effects of glyphosatecommercial formulation on Apis mellifera ligustica and Apis ceranacerana[J]. Science of the Total Environment, 2020, 744: 140819.
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https://www.sciencedirect.com/science/article/pii/S0048969720343436?via%3Dihub
ZhengM, Wu C, Yang K, et al. Novelselective hexokinase 2 inhibitor Benitrobenrazide blocks cancer cellsgrowth by targeting glycolysis[J].Pharmacological Research, 2021, 164: 105367.
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https://www.sciencedirect.com/science/article/pii/S1043661820316753?via%3Dihub
ZhouR, Yu Q, Li T, et al. Carcassdecomposition influences the metabolic profiles and enriches noxiousmetabolites in different water types by widely targeted metabolomics[J]. Chemosphere, 2021, 269: 129400.
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https://www.sciencedirect.com/science/article/pii/S0045653520335980?via%3Dihub
TangX, Wang W, Hong G, et al. Gutmicrobiota-mediated lysophosphatidylcholine generation promotescolitis in intestinal epithelium-specific Fut2 deficiency[J]. Journal of biomedical science, 2021, 28(1): 1-17.
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https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-021-00711-z
LiuH, Zhang X, Xiao J, et al. Astaxanthinattenuates d-galactose-induced brain aging in rats by amelioratingoxidative stress, mitochondrial dysfunction, and regulating metabolicmarkers[J].Food & function, 2020, 11(5): 4103-4113.
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https://pubsrsc.53yu.com/en/content/articlelanding/2020/fo/d0fo00633e/unauth
DuR, Bei H, Jia L, et al. DangguiBuxue Tang restores antibiotic-induced metabolic disorders byremodeling the gut microbiota[J].Journal of ethnopharmacology, 2020, 259: 112953.
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https://sciencedirect.53yu.com/science/article/abs/pii/S0378874120311351
ZhengS, Liu T, Liu Q, et al. Widelytargeted metabolomic analyses unveil the metabolic variations afterstable knock-down of NME4 in esophageal squamous cell carcinomacells[J].Molecular and Cellular Biochemistry, 2020, 471(1): 81-89.
Article link>
https://linkspringer.53yu.com/article/10.1007/s11010-020-03768-w
LiW, Li Z, Peng M J, et al. OenotheinB boosts antioxidant capacity and supports metabolic pathways thatregulate antioxidant defense in Caenorhabditis elegans[J]. Food & function, 2020, 11(10): 9157-9167.
Article link>
https://sci-hub.se/10.1039/d0fo01635g
HuangS, Cao Q, Cao Y, et al. Morindaofficinalis polysaccharides improve meat quality by reducingoxidative damage in chickens suffering from tibialdyschondroplasia[J].Food Chemistry, 2021, 344: 128688.
Article link>
https://sciencedirect.53yu.com/science/article/abs/pii/S0308814620325504
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2019
XiaoY, Li X, Zeng X, et al. Alow ω-6/ω-3 ratio high-fat diet improves rat metabolism via purineand tryptophan metabolism in the intestinal tract, while reversed byinulin[J]. Journal of agricultural and food chemistry, 2019, 67(26):7315-7324.
Article link>
https://pubsacs.53yu.com/doi/abs/10.1021/acs.jafc.0c01778
SunL, Kang Q, Pan Y, et al. Serummetabolite profiling of familial adenomatous polyposis using ultraperformance liquid chromatography and tandem mass spectrometry[J].Cancer Biology & Therapy, 2019, 20(7): 1017-1028.
Article link>
https://wwwtandfonline.53yu.com/doi/abs/10.1080/15384047.2019.1595277
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