斑马鱼心电采集和分析系统顾名思义是用于斑马鱼心电信号采集和分析的系统,主要应用于:心血管相关药物研发测试、心脏毒理测试、动物实验模型的构建等。本文将重点介绍两款实验室常用的斑马鱼心电采集设备和应用,分别来自美国iworx公司和德国MDE公司的斑马鱼心电采集和分析系统。
图片来源网络
目前,斑马鱼在心脏药理、毒理和疾病模型等领域发挥着越来越重要的作用,对斑马鱼心功能的评估是这些领域不可避免的问题。俗话说,工欲善其事必先利其器,本文以下将介绍几款斑马鱼心电采集和分析系统,以及其文献应用示例:
iWorx——斑马鱼心电采集和分析系统
采集器用于记录和优化斑马鱼微伏数量级的ECG信号。正常斑马鱼心电在30-200uV之间,该系统噪音低至1微伏,因此具有提供非常高的信噪比,可用于精确分析ECG信号的微弱变化。
应用示例1:
MDE——CARDIOFISH斑马鱼心电采集系统
机械单元 工作站和分析软件 操作臂、电极和载鱼台
使用案例:
iWorx和MDE区别和对比:
斑马鱼其他相关设备
产品相关文献:
1) Da Silveira Cavalcante L, Tessier SN. Zebrafish as a New Tool in Heart Preservation Research. J Cardiovasc Dev Dis. 2021;8(4):39. Published 2021 Apr 8. doi:10.3390/jcdd8040039
2) Howe K, Clark MD, Torroja CF, et al. The zebrafish reference genome sequence and its relationship to the human genome [published correction appears in Nature. 2014 Jan 9;505(7482):248. Cooper, James [corrected to Cooper, James D]; Eliott, David [corrected to Elliot, David]; Mortimer, Beverly [corrected to Mortimore, Beverley]; Begum, Sharmin [added]; Lloyd, Christine [added]; Lanz, Christa [added]; Raddatz, Günter [added]; Schuster, Ste]. Nature. 2013;496(7446):498-503. doi:10.1038/nature12111
3) Echeazarra L, Hortigón-Vinagre MP, Casis O, Gallego M. Adult and Developing Zebrafish as Suitable Models for Cardiac Electrophysiology and Pathology in Research and Industry. Front Physiol. 2021;11:607860. Published 2021 Jan 13. doi:10.3389/fphys.2020.607860
4) Santoso F, Farhan A, Castillo AL, et al. An Overview of Methods for Cardiac Rhythm Detection in Zebrafish. Biomedicines. 2020;8(9):329. Published 2020 Sep 4. doi:10.3390/biomedicines8090329
5) Ling D, Chen H, Chan G, Lee SM. Quantitative measurements of zebrafish heartrate and heart rate variability: A survey between 1990-2020. Comput Biol Med. 2022;142:105045. doi:10.1016/j.compbiomed.2021.105045
6) Patton EE, Zon LI, Langenau DM. Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials. Nat Rev Drug Discov. 2021;20(8):611-628. doi:10.1038/s41573-021-00210-8
7) Yan J, Li H, Bu H, et al. Aging-associated sinus arrest and sick sinus syndrome in adult zebrafish. PLoS One. 2020;15(5):e0232457. Published 2020 May 13. doi:10.1371/journal.pone.0232457
8) Liu H, Chen X, Zhao X, et al. Screening and Identification of Cardioprotective Compounds From Wenxin Keli by Activity Index Approach and in vivo Zebrafish Model. Front Pharmacol. 2018;9:1288. Published 2018 Nov 13. doi:10.3389/fphar.2018.01288
关于玉研
上海玉研科学仪器有限公司是专业为动物实验、动物研究领域提供科学仪器和技术服务的公司。我们着力引进国外的先进科学仪器和实践经验,选择使用广泛、应用成熟、性能先进的实验仪器和实验方法,为国内实验室建设、研究课题进展提供科学、合理的解决方案。
iWorx和MDE是上海玉研的长期合作伙伴,上海玉研作为他们在中国的首席代理公司,可代为销售他们公司的所有产品,并享有优价权,更多信息欢迎咨询我们:021-35183767
扫码关注