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上市时间：2021年5月
新增了AAV衣壳滴度，AAV空壳率，LNP总RNA定量等参数分析
病毒、疫苗快速表征仪
浓度定量、粒径检测
Stunner是—款仅需2μL样品， 即可整合紫外／可见光(UV/Vis)浓度定量、动态光散射和静态光散射数据的系统。将蛋白和ssDNA浓度与光散射结合， 以获得总衣壳滴度和空壳率。仅需—次操作便可检测出浓度、流体力学粒径、多分散性和聚集体， 从而确定蛋白质的质量。不错过任何细节， 让您真正了解您的AAV或蛋白是否合适。
只需将2μL的样品加入Stunner的检测芯片一既不需要样品前处理， 也不需要稀释。 每—个微流控环路连接两个固定光程的检测池， 覆盖0.03-275 OD动态检测范围。 如果需要测试整板96个样品浓度， 10分钟之内即可完成；若同时启动DLS测定粒径， 在1小时之内即可完成全部工作。 即使再多样品， 将Stunner与移液工作站连接， 让大批量样品的定星工作轻松、 高效到不可思议！
· AAV衣壳滴度
· AAV空壳率
· LNP总RNA定量
· 聚集
· 浓度
· 粒径和多分散性
· B22 & KD
Stunner is the only system that pulls together UV/Vis concentration, Dynamic Light Scattering (DLS) and Static Light Scattering (SLS) data from the same 2 μL sample. Dig in to your AAV to get the total capsid titer and empty/full ratio, or rack up payload concentration and size data on any nanoparticle all at once. Nail down your protein quality by knocking concentration, hydrodynamic size, polydispersity, and detection of aggregates off your list in one shot. Without skipping a beat, you’ll know if your AAV, nanoparticle or protein is good to go. Get brochure.
AAV capsid titer
AAV empty/full ratio
LNP total RNA quant
Nanoparticle payload quant
Aggregation
Concentration
Sizing & polydispersity
B22 & kD
Stunner是—款仅需2μL样品， 即可整合紫外／可见光(UV/Vis)浓度定量、动态光散射和静态光散射数据的系统。将蛋白和ssDNA浓度与光散射结合， 以获得总衣壳滴度和空壳率。仅需—次操作便可检测出浓度、流体力学粒径、多分散性和聚集体， 从而确定蛋白质的质量。不错过任何细节， 让您真正了解您的AAV或蛋白是否合适。
AAV 衣壳滴度
AAV 空/满比率
LNP 总RNA定量
纳米粒子有效载荷定量
集合体
浓度
尺寸和多分散性
B22& kD
Just load 2 μL of sample in a Stunner plate — don’t bother with sample prep or dilution. Each microfluidic circuit has two fixed pathlengths built into it to cover a wide dynamic range of 0.03-275 OD. If you’re dealing with a full plate, get 96 concentration measurements in 10 minutes — add on DLS sizing and have both done in an hour. For even heavier workflows, hook it up to your favorite robot to add more oomph.
只需将2μL的样品加入Stunner的检测芯片一既不需要样品前处理， 也不需要稀释。 每—个微流控环路连接两个固定光程的检测池， 覆盖0.03-275 OD动态检测范围。 如果需要测试整板96个样品浓度， 10分钟之内即可完成；若同时启动DLS测定粒径， 在1小时之内即可完成全部工作。 即使再多样品， 将Stunner与移液工作站连接， 让大批量样品的定量工作轻松、 高效到不可思议！
Drop in your AAV and before you can blink, DLS & SLS figure out how many intact capsids you have or if a bunch of aggregates are screwing things up. See empty/full ratio, total protein and total ssDNA in about a minute with UV/Vis. Don’t worry about extinction coefficients or overlapping spectra – Stunner does all the math for you.
放入您的AAV，在您眨眼之前，DLS和SLS会找出您有多少个完整的衣壳，或者一堆聚合体是否搞砸了事情。使用UV /Vis在大约一分钟内看到空壳率，总蛋白质和总ssDNA，不要担心消光系数或重叠光谱 - Stunner为您完成所有数学运算。
Get to the numbers you actually want – titers. Stunner bridges DLS and UV/Vis data to tally up how many full and empty capsids are present, and how much extra protein and DNA is left over. Take your cleaned up AAV and sneak a peek down to 1012 vg/mL. In just one assay, Stunner’s dye-free, label-free, standard-free, hassle-free workflow tells the whole titer story.
获得您真正想要的数字 - 滴度。Stunner将DLS和UV / Vis数据连接起来，以计算存在多少个完整的和空的衣壳，以及还剩下多少额外的蛋白质和DNA。拿起你清理过的AAV，偷偷看一眼1012vg/mL.只需一次检测，Stunner 的无染料、无标签、无标准、无忧的工作流程即可讲述整个滴度的故事。
Every AAV is different, but Stunner figures them all out. Pick a preloaded serotype or feed in the specs for your virus and get answers in seconds. Now you can check capsid titers and empty/full ratio as often as you want.
每个AAV都是不同的，但Stunner把它们都弄清楚了。为你的病毒挑选一个预加载的血清型或输入样本，几秒钟内就能得到答案。现在你可以随时检查衣壳滴度和空壳率。
Globs of AAV can stand between you and high-quality data for pretty much every assay. DLS checks if your AAV is monodisperse so the rest of your process doesn’t get tripped up by aggregates.
AAV的球状物几乎可以阻止你获得每项检测的高质量数据。DLS会检查AAV是否是单分散的，以便流程的其余部分不会被聚合绊倒。
Cloudy solutions of LNPs and other nanoparticles hang up other techniques but Stunner’s short pathlengths teamed up with DLS and UV/Vis get you the answers you need. Cut through all that turbidity with Unmix and check out just the absorbance signal from your payload.
LNP和其他纳米颗粒的浑浊溶液挂起了其他技术，但Stunner的短路径长度与DLS和UV / Vis配合使用，可为您提供所需的答案。使用Unmix消除所有浊度，并仅检查有效载荷的吸光度信号。
Teach Stunner all about the UV/Vis absorbance of your nanoparticle and it will spot exactly the signal you want to know about. Skip the disruption step and quantify any payload: RNA, DNA, any protein or whatever small molecule. Stunner makes quantification crazy simple to free you from complicated disruption workflows, costly dyes, and wasteful standard curves.
教Stunner所有关于纳米颗粒的紫外/可见光度的知识，它将准确地发现你想知道的信号。跳过破坏步骤，量化任何有效载荷：RNA、DNA、任何蛋白质或任何小分子。Stunner 使定量变得特别简单，让您从复杂的中断工作流程、昂贵的染料和耗时的标准曲线制作中解脱出来。
Stunner’s DLS gives you the high-throughput power to round up size and size distribution data on 96 nanoparticle samples in less than 1 hour. Walk away from one-by-one DLS that requires tons of sample and hefty hands-on time. Beef up your sizing statistics with as many replicates as you want and minimize your time at the bench.
Stunner 的 DLS 为您提供了高通量能力，可在不到 1 小时的时间内汇总 96 个纳米颗粒样品的尺寸和尺寸分布数据。远离需要大量样品和大量动手时间的逐个DLS。通过尽可能多的重复来加强您的尺码统计数据，并最大限度地减少您在工作台上的时间。
Stunner pulls rank on other systems because it’s way, way more than just DLS. It lets you get a grip on what storage, agitation or a change to your process or formulation does to your protein. See if there’s any aggregation, measure the hydrodynamic size, grab polydispersity when you need to check uniformity, and get the exact concentration while you’re at it.
Stunner在其他系统上排名很高，因为它不仅仅是DLS。它使您可以掌握储存，搅拌，改变工艺或配方对蛋白质的影响。查看是否有任何聚集体，测量流体动力学尺寸，在需要检查均匀性时获取多分散性，并在使用时获得准确的浓度。
Stunner is the only system out there that can measure biologics at high-throughput and high concentration. It’s got dynamic range that covers from 0.02 mg/mL to 200 mg/mL (mAb), so run any protein without ever having to dilute again. Stop the madness of running just one protein at a time — and cleaning up afterwards.
Stunner是唯一可以高通量和高浓度测量生物制剂的系统。它的动态范围从0.02 mg / mL到200 mg / mL（mAb），因此无需再次稀释即可运行任何蛋白质。您不必再为一次只运行一种蛋白质- 然后清理的过程抓狂。
Get spot-on precision within 1% and accuracy within 2%. Using two fixed pathlengths, Stunner gets you jaw-dropping data at both low and high protein concentrations and nails the expected concentrations every time. With the smallest sample size, the highest throughput and crazy accurate results, Stunner is hands down the best tool out there for protein quantification.
精度在1%以内，精度在2%以内。通过使用两个固定的路径长度，Stunner可以在低蛋白浓度和高蛋白浓度下获得令人瞠目结舌的数据，并确定每次的预期浓度。凭借最小的样本量、最高的通量和特别准确的结果，Stunner无疑是蛋白质定量的最佳工具。
On the fly data tells you if your sample’s in good shape, or if aggregation is in the cards. Because the concentration of each sample in the series is measured in real time with DLS, you get the most accurate values without breaking a sweat.
即时数据告诉您样本是否处于良好状态，或者聚合是否存在。由于该系列中每个样本的浓度都是使用DLS实时测量的，因此您可以在不出任何差错的情况下获得最准确的值。
Pin down what else is going on with your sample, or just check out its other characteristics. Pick a few wavelengths, a background subtraction method, and create your favorite equation. Stunner’s Homebrew tool is wide open, so you can create apps just the way you like them.
确定你的样品还有什么其他的变化，或者只是看看它的其他特征。选择几个波长，一种背景减法，然后创建你最喜欢的方程。Stunner的自制工具是完全开放的，因此你可以按照自己喜欢的方式创建应用程序。
Stunner has shocking accuracy and wants to prove it. Using the Fundamentals tryptophan standards, the accuracy, precision and linearity of the instrument can be proven at any time – at the protein-relevant 280 nm wavelength and OD range of 20-225. Be confident about every sample with data that leaves no room for doubt.
Stunner具有令人震惊的准确性，并希望证明这一点。使用 基础色氨酸标准品，可以随时证明仪器的准确性、精密度和线性-在蛋白质相关的280 nm波长和OD范围为20-225。对每一个样本都要充满信心，数据不容怀疑。
Smash through the USP & Ph. Eur. UV/Vis requirements for absorbance accuracy, precision, linearity, wavelength accuracy, stray light and resolution with performance verification measurements of independently certified NIST standards. Stunner is ready when you are to get validated and make the move into QC.
突破美国药典和欧洲药典中，关于吸收度精度、精密度、线性度、波长精度、杂散光和分辨率的紫外/可见光的要求，以及独立认证的NIST标准的性能验证测量。当您要获得验证并进入QC时，Stunner已准备就绪。
GLP labs don’t sweat it. Stunner’s software hooks labs up with 21 CFR Part 11 compliant features. We’re talking password protection, electronic signatures, full audit trail — the whole package.
GLP实验室不必担心。Stunner的软件将实验室与21 CFR Part 11兼容的功能挂钩。我们谈论的是密码保护、电子签名、完整的审计跟踪——整个软件包。
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