Acetyl CoA Carboxylase 1(ACC1)(ACACA)antibody
Cat.#: 3495-1
Rabbit Monoclonal Antibody
Clone ID: EPR4971
Swiss Prot: Q13085
Mol Weight: 265kDa
Size: 100ul
Description
Acetyl-CoA Carboxylase 1 (ACC1) is a biotin dependent lipogenic enzyme that is highly expressed during adipogenesis. ACC1 catalyzes acetyl-CoA carboxylation, producing malonyl-CoA, a metabolite involved in energy homeostasis regulation. Malonyl-CoA is a two carbon donor in the synthesis of long-chain fatty acids and the elongation of fatty acids found in the cystol (1). ACC1 is regulated short-term by citrate, CoA, and palmitoyl-CoA through allosteric interactions. Nutrients and hormones can be both short-term (inducing reversible phosphorylations by such as AMPK) and long-term (transcription level regulation) regulators of ACC1 (2). Highly expressed in lipogenic tissues, ACC1 is found in liver, adipose, and lactating mammary gland (3). ACC1 has been implicated as a target in the development of anti-obesity drugs (4).
Recommended Applications
WB, IHC, ICC, FC
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IHC: 1:250 - 500
ICC: 1:100 - 250
FC: 1:100 - 500
Species Reactivity
Human, Mouse, Rat
Mouse cross reactivity tested by western blot and IHC
Rat cross reactivity tested by western blot only
Products Data
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Immunofluorescent staining of 293 cells using anti-Acetyl CoA Carboxylase 1 (ACC1) RabMAb (cat. #3495-1).
Specificity
A synthetic peptide corresponding to residues in N-terminus of human Acetyl CoA Carboxylase 1 (ACC1) was used as an immunogen.
Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Alternative Names
ACACA antibody, ACAC antibody, ACC antibody, ACC1 antibody, ACCA antibody, Biotin carboxylase antibody, ACC-alpha antibody
Description References
1. Jianqiang M, et al. PNAS 100:7515-7520, 2003
2. Girad J, et al. The FASEB Journal 8:36-42, 1994
3. Wakil SJ, et al. Annu Rev Biochem 52:537-539
4. Abu-Elheiga L, et al. Science 291: 2613-2616. 2001