AMSH(STAMBP)antibody
Cat.#: 3219-1
Rabbit Monoclonal Antibody
Clone ID: EPR4361
Swiss Prot: O95630
Mol Weight: 48kDa
Size: 100ul

Description
Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains a SH3 domain that is required for induction of MYC and cell growth. AMSH is a deubiquitinating enzyme that binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression (1).

Recommended Applications
WB, ICC

Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
ICC: 1:100 - 250

Species Reactivity
Human, Mouse, Rat

Mouse and Rat reactivity predicted based on sequence analysis, not based on testing

Products Data

Western blot analysis on (A) Jurkat, (B) HeLa, (C) Raji, and (D) SW480 cell lysates using anti-AMSH RabMAb (cat. #3219-1).

Specificity
A synthetic peptide corresponding to residues in human AMSH was used as an immunogen.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
STAMBP antibody, AMSH antibody, MGC126516 antibody, MGC126518 antibody, STAM-binding protein antibody, Associated molecule with the SH3 domain of STAM antibody, Endosome-associated ubiquitin isopeptidase antibody