ALS2 Antibody(C-term)
Cat.#: T1417
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: Q96Q42
Mol Weight: 184kDa
Size: 100ug

Description
ALS2 contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in its gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis.

Recommended Applications
WB, IHC, ELISA

Applications and Recommended Dilution Factors
WB: 1:50~100
IHC: 1:50~100
ELISA: 1:1,000

Species Reactivity
Human, Mouse

Products Data

Western blot analysis of ALS2 antibody (C-term) in mouse lung tissue lysates (35ug/lane). ALS2 (arrow) was detected using the purified Pab.

Specificity
This ALS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1255~1285 amino acids from the C-terminal region of human ALS2.

Storage Condition and Buffer
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Alternative Names
ALS2 antibody, ALS2CR6 antibody, ALSJ antibody, FLJ31851 antibody, IAHSP antibody, KIAA1563 antibody, MGC87187 antibody, PLSJ antibody, Alsin antibody, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein antibody, Amyotrophic lateral sclerosis 2 protein antibody

Description References
Soares,D.C., J Mol Model 15 (2), 113-122 (2009)
Mintchev,N., Neurology 72 (1), 28-32 (2009)