| Catalogue Number | ANT-263 |
| Synonyms | p50, Bp50, CDW40, MGC9013, TNFRSF5, CD40. |
| Type | Mouse Anti Human Monoclonal. |
| Introduction | CD40 is part of the TNF-receptor superfamily. CD40 is a necessary mediator for vast range of immune and inflammatory responses together with T cell-dependent immunoglobulin class switching, memory B cell growth, and germinal center formation. The transcription factor AKNA regulates the expression of CD40 and its ligand, which is vital for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and serves as a mediator of the signal transduction. The interaction of CD40 and its ligand is crucial for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is the receptor for TNFSF5/CD40L. |
| Clone | hCD40. |
| Immunogen | Activated Human B cells. |
| Ig Subclass | Mouse IgG1. |
| Purification Method | Protein-A. |
| Protein concentration | 1mg/ml in PBS (after reconstitution). |
| Storage Procedures | Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C. |
| Reconstitution | Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Stability / Shelf LifeTwo years lyophilized, one month in solution at 4°C. |
| Antibody Properties | Staining antibody. For staining, use 10µl/106 cells. |
| Available Conjugates | This antibody is also available conjugated to biotin and FITC. For staining with biotin or FITC-conjugated antibody use 5-10µl/106 cells. |
| Usage | ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
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