AChRalpha4 antibody
Cat.#: S2863
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: P43681
Mol Weight: 70.04kDa
Size: 100ul

Description
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. [provided by RefSeq]

Recommended Applications
WB

Applications and Recommended Dilution Factors
WB: 1:500-1:3000

Species Reactivity
Human

Other species have not been tested

Products Data 

 

Sample (30ug of whole cell lysate)
A: 293T
B: H1299
C: Hep G2
D: Molt-4
7.5% SDS PAGE
diluted at 1:1000
Immunohistochemical analysis of paraffin-embedded DLD-1 xenograft , using Nicotinic Acetylcholine Receptor alpha 4 antibody at 1:100 dilution.

Specificity
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 74 and 314 of Human CHRNA4

Storage Condition and Buffer
0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. Purified by antigen-affinity chromatography.

Alternative Names
CHRNA4 antibody, BFNC antibody, EBN antibody, EBN1 antibody, FLJ95812 antibody, NACHR antibody, NACHRA4 antibody, NACRA4 antibody, Neuronal acetylcholine receptor subunit alpha-4 antibody, antibody