ACVR2B Antibody(N-term)
Cat.#: T2022
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: Q13705
Mol Weight: 58kDa
Size: 100ug

Description
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. ACVR2B (activin A type IIB receptor) displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.

Recommended Applications
WB, IHC, ELISA

Applications and Recommended Dilution Factors
WB: 1:100~500
IHC: 1:50~100
ELISA: 1:1,000

Species Reactivity
Human

Products Data 

 

Western blot analysis of ACVR2B N-term S14 in Jurkat cell line lysates (35ug/lane).ACVR2B (arrow) was detected using the purified Pab.
Western blot analysis of anti-ACVR2B Antibody (N-term) in mouse heart, kidney and brain lysates (35ug/lane). ACVR2B (arrow) was detected using the purified Pab.

Specificity
This ACVR2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ACVR2B.

Storage Condition and Buffer
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Alternative Names
ACVR2B antibody, ACTRIIB antibody, ActR-IIB antibody, MGC116908 antibody, Activin receptor type-2B antibody, Activin receptor type IIB antibody

Description References
Harrison, C.A., et al., J. Biol. Chem. 279(27):28036-28044 (2004).
Martins da Silva, S.J., et al., Dev. Biol. 266(2):334-345 (2004).
Casagrandi, D., et al., Mol. Hum. Reprod. 9(4):199-203 (2003).
Shin, B.K., et al., J. Biol. Chem. 278(9):7607-7616 (2003).
Schneider-Kolsky, M.E., et al., Placenta 23(4):294-302 (2002).