| Catalogue Number | ANT-409 |
| Synonyms | Caspase-2, CASP-2, Protease ICH-1 Neural precursor cell expressed developmentally down-regulated protein 2, NEDD-2, CASP2, ICH1, NEDD2, ICH-1L, ICH-1L/1S. |
| Type | Mouse Anti Human Monoclonal. |
| Introduction | Caspase-2 is a protein which belongs to the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases has a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The proteolytic cleavage of Caspase-2 is induced by a variety of apoptotic stimuli. |
| Clone | P1C10AT. |
| Immunogen | Anti-human Caspase-2 mAb, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human Caspase-2 amino acids 32-169 purified from E. coli. |
| Ig Subclass | Mouse IgG2b heavy chain and κ light chain. |
| Purification Method | Caspase-2 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. |
| Protein formulation | 1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide. |
| Storage Procedures | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
| Stability / Shelf Life | 12 months at -20°C. 1 month at 4°C. |
| Applications | Caspase-2 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1,000. Recommended starting dilution is 1:500. |
| Usage | ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
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