5-Aza-2′-deoxycytidine
别名: 2′-Deoxy-5-azacytidine, 4-Amino-1-(2-deoxy-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one, Decitabine
CAS号: 2353-33-5
分子量: 228.21
General description
Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling “opening” chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.
Biochem/physiol Actions
5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by "opening" the chromatin structure detectable as increased nuclease sensitivity. This remodeling of chromatin structure allows transcription factors to bind to the promoter regions, assembly of the transcription complex, and gene expression.
相关类型 AN-AZ, Antitumor Agents, Bioactive Small Molecules, Cancer Research, Cell Biology,
Cell Signaling and Neuroscience, Gene Regulation, Gene Regulation and Expression
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assay ≥97%
solubility acetic acid: water (1:1): soluble50 mg/mL