5-氮杂胞嘧啶核苷
5-Azacytidine
别名: 4-氨基-1-(β-D-呋喃核糖基)-1,3,5-三嗪-2(1H)-酮, 阿扎胞苷
CAS号: 320-67-2
分子量: 244.20
Biochem/physiol Actions
Causes DNA demethylation or hemi-demethylation, creating openings that allow transcription factors to bind to DNA and reactivate tumor suppressor genes.
一种强效生长抑制剂及细胞毒素剂，抑制 DNA 甲基转移酶，一种基因表达、基因激活和沉默的重要调节机制。
相关类型 A - K, AN-AZ, Antibacterial, Antibiotics, Antibiotics A to Z,
Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Antitumor Agents, Antiviral, Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure Class, DNA Methyltransferase Inhibitors, Gene Regulation, Gene Regulation and Expression, Interferes with DNA Synthesis, Mechanism of Action, Nucleoside analog inhibitors, Nucleosides, Small Molecules for Stem Cell Biology, Spectrum of Activity, Stem Cell Biology
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assay ≥98% (HPLC)
mp 226-232 °C (dec.)(lit.)
storage temp. −20°C