Product Specification Alternative Name: 5-Amino-[(N-2,5-dihydroxybenzyl)-N'-2-hydroxybenzyl]salicylic acid, RG14355 Formula: C21H19NO6 MW: 381.4 Purity: ≥98% Appearance: Off-white to tan solid. CAS: 125697-92-9 Solubility: Soluble in DMSO or ethanol. Shipping: AMBIENT Long Term Storage: +4°C Use/Stability: Stable for at least 1 year after receipt when stored, as supplied, at 0-4°C. Prepare solutions fresh daily. Handling: Protect from oxygen. Replaces Prod. #: ALX-350-007 Cell permeable tyrosine kinase inhibitor with little effect on cAMP-dependent protein kinase (PKA) or protein kinase C (PKC). Potent and selective inhibitor of the EGF receptor tyrosine kinase (IC50=11nM). Binds to a site on the kinase which is distinct from the ATP and peptide substrate binding sites. Inhibits EGF-induced proliferation of cultured human myometrial smooth muscle cells and suppresses VEGF-induced angiogenesis in rats. Effective at 10µM in cultured leech neurons. Also inhibits NMDA-stimulated cGMP production.