Product Specification Alternative Name: CsA Formula: C62H111N11O12 MW: 1202.6 Purity: ≥98% Appearance: White solid. CAS: 59865-13-3 Source/Host: Isolated from Fusarium solani Solubility: Soluble in DMSO (25mg/ml), methanol, 100% ethanol (25mg/ml), acetone or petroleum ether; insoluble in water. Shipping: AMBIENT Long Term Storage: -20°C Use/Stability: Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. Hazard: HARMFUL. MAY BE CARCINOGENIC. MAY BE TERATOGENIC. Replaces Prod. #: ALX-380-002 Cyclosporin A (CsA) is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. CsA binds to cyclophilin and suppresses its proline rotamase activity. The CsA-cyclophilin complex inhibits calcineurin, a type 2B phosphatase. It is an important diagnostic tool for the characterization of permeability transition-related phenomena. It inhibits mitochondrial permeability transition pore opening however, pore inhibition becomes less efficient at increasing Ca2+ loads and inhibition is transient. Inhibits staurosporin-induced apoptosis in cultured neural cells and rotenone-induced apoptosis in PC-12 cells. Inhibits cytochrome c release from mitochondria. Inhibits nitric oxide (NO) synthesis.