产品描述
Embelin is a novel cell-permeable inhibitor of XIAP (X-linked inhibitor of apoptosis) which was discovered by screening a library of natural products derived from traditional Chinese medicine. It binds to the XIAP BIR3 domain preventing its binding to and inhibition of caspase-9 and effector caspases. Embelin selectively inhibits cell growth in cancer cells expressing high levels of XIAP (IC50 = 3-6 µM) versus normal cells with low levels of XIAP.
Product Specification
Formula: C17H26O4
MW: 294.4
Purity: ≥98%
Appearance: Orange solid
CAS: 550-24-3
Solubility: Soluble in DMSO (10mg/ml)
Shipping: AMBIENT
Long Term Storage: -20°C
