Mdivi-1 is a selective inhibitor of mitochondrial division in yeast and mammalian cells which acts via inhibiting the mitochondrial division dynamin. In cells, Mdivi-1 inhibits apoptosis by inhibiting mitochondrial outer membrane permeabilization. Mdivi-1 causes the rapid (<5 min) reversible and dose-dependent formation of net-like mitochondria in wild-type cells with an IC50= ~10µM. In yeast, time-lapse fluorescence microscopy revealed no detectable mitochondrial division after treatment with Mdivi-1.
It inhibits Dnm1 GTPase activity in a dose dependent manner with an estimated IC50 of 1-10µM but is not a general inhibitor of GTPases.
Product Specification
Formula: C15H10Cl2N2O2S
MW: 353.2
Purity: ≥98% (TLC)
Appearance: White solid.
CAS: 338967-87-6
Solubility: Soluble in DMSO (25mg/ml).
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C