Members of the cytochrome P-450 1A (CYP1A) sub-family are induced by a range of polycyclic aromatic compounds such as benzpyrene, 3-methylcholanthrene (Cat. # GR-239), and pro-carcinogenic heterocyclic aromatic amines. Cigarette smoking has been reported to induce CYP1A2 in human liver, and appears to be a major catalyst in the hepatic activation of PhIP, (2-amino-1-methyl-6-phenylimidazo[4,5,b]-pyridine). The mono-oxygenase inhibitor inhibitor enoxacin induces CYP1A2 in rat liver, whereas a related compound ciprofloxacin does not. Product Specification Alternative Name: CYP1A2 Immunogen: Synthetic peptide corresponding to the internal domain (aa 284-298) of human CYP1A2. Source/Host: From rabbit. Specificity: Recognizes human CYP1A1. Not suitable for use on rat tissue. Application: Immunohistochemistry (frozen sections; paraffin sections) Western Blot Shipping: SHIPPED ON BLUE ICE Long Term Storage: -20°C