Members of the cytochrome P-450 1A (CYP1A) sub-family are induced by a range of polycyclic aromatic compounds such as benzpyrene, 3-methylcholanthrene (Cat. # GR-239), and pro-carcinogenic heterocyclic aromatic amines. Cigarette smoking has been reported to induce CYP1A2 in human liver, and appears to be a major catalyst in the hepatic activation of PhIP, (2-amino-1-methyl-6-phenylimidazo[4,5,b]-pyridine). The mono-oxygenase inhibitor enoxacin induces CYP1A2 in rat liver, whereas a related compound ciprofloxacin does not.
Product Specification
Alternative Name: CYP1A2
Immunogen: Synthetic peptide corresponding to the C-terminus of rat CYP1A2.
Source/Host: From sheep.
Specificity: Recognizes rat CYP1A2. Not suitable for use on human tissue.
Application: Immunohistochemistry (frozen sections)
Western Blot
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C