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An adenosine analog that is phosphorylated in whole cells to form 5-aminoimidazole-4-carboxamide-1-D-ribofuranosyl-5’-monophosphate (ZMP), which stimulates AMPK activity. AICAR acts by entering nucleoside pools, significantly increasing levels of adenosine during periods of ATP breakdown. Induces the phosphorylation of TORC2 and inhibits its entry into the nucleus. Mimics the effects of insulin on the expression of two gluconeogenic genes PEPCK and glucose-6-phosphatase. Inhibits PPARα coactivation and adipocyte differentiation.
Substrate for the AICAR transformylase activity of ATIC. Inhibits the growth of prostate cancer cells by inhibiting fatty ascid synthesis. Supresses LPS-induced TNF production via the inhibition of Akt activation. Induces apoptosis in Jurkat cells via a non-AMPK pathway.
Product Specification
Alternative Name: 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside, Acadesine
Formula: C9H14N4O5
MW: 258.2
Purity: ≥99% (TLC)
Appearance: Off-white solid.
CAS: 2627-69-2
Solubility: Soluble in water (9mg/ml)
Shipping: AMBIENT
Long Term Storage: -20°C
Hazard: HARMFUL.