Triciribine

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属性:产地:; 品牌:Biomol ;货期:现货

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Triciribine is a synthetic tricyclic nucleoside which acts as a specific inhibitor of the Akt signaling pathway. It selectively inhibits the phosphorylation and activation of Akt1, -2 and -3 but does not inhibit Akt kinase activity nor known upstream Akt activators such as PI 3-Kinase and PDK1. It inhibits cell growth and induces apoptosis preferentially in cells that express aberrant Akt1. In whole cells triciribine is phosphorylated by adenosine kinase which may be necessary for its activity.
Product Specification
Formula: C13H16N6O4
MW: 320.3
Purity: ≥98% (HPLC)
Appearance: Pale yellow solid
CAS: 35943-35-2
Solubility: Soluble in DMSO
Shipping: AMBIENT
Long Term Storage: -20°C
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