BML-275

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Cell-permeable pyrrazolopyrimidine derivative that inhibits AMP kinase (Ki=109 nM in the absence of AMP) in an ATP-competitive manner. It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. Decreases food intake in mice and inhibits the effects of AICAR and metformin. It has been shown to inhibit BMP type I receptors ALK2, ALK3 and ALK6.
Product Specification
Alternative Name: Compound C, Dorsomorphin
Formula: C24H25N5O
MW: 399.5
Purity: ≥98% (HPLC)
Appearance: Yellow solid
CAS: 866405-64-3
Solubility: Soluble in DMSO (4mg/ml, warm)
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C
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