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Replaces Prod. #: ALX-380-281
Inhibitor of a variety of serine/threonine and tyrosine kinases, like protein kinase C (PKC), cyclic AMP-dependent protein kinase (PKA), S6 kinase, Akt (protein kinase B; PKB), epidermal growth factor receptor (EGFR) tyrosine kinase activity and others including  KDR, VEGFR, PDGFR, c-kit and other receptor tyrosine kinases. Potently inhibits FLT-3 kinase including mutant forms found in acute myeloid leukemia in vitro and in vivo. Apoptosis inducer. Showed broad antiproliferative activity against various tumor cell lines.
Selectively inhibits T lymphocyte production of TNF-α. Upregulates endothelial nitric oxide synthase (eNOS; NOS III). Abrogates tumor angiogenesis in vivo.
Product Specification
Alternative Name: 4’-N-Benzoyl-staurosporine, Midostaurin, CGP 41251
Formula: C35H30N4O4
MW: 570.6
Purity: ≥98% (TLC)
Appearance: White to off-white powder.
CAS: 120685-11-2
MI: 14: 6185
Solubility: Soluble in DMSO (15mg/ml), MDC (10mg/ml), methanol (5mg/ml) or 100% ethanol (2.5mg/ml).
Shipping: AMBIENT
Long Term Storage: -20°C
Use/Stability: Stable for up to 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.