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Inhibitor of intracellular protein transport and protein secretion, interfering with trafficking in the trans-Golgi network, leading to the accumulation of cycling proteins in ERGIC clusters. Blocks ADP-ribosylation factor (Arf) in an inactive GDP-bound conformation and thereby prevents binding of COPI coats to ERGIC and Golgi membranes. Upon brefeldin A treatment the Golgi rapidly tubulates and fuses with the ER by an energy-, temperature-, and microtubule-dependent process. In contrast, the drug has little effect on the ERGIC, which keeps its identity, although the ERGIC clusters become larger and more uniformly distributed in the cytoplasm of the cells.
Inhibits intracellular collagen degradation. Also inhibits apical Na+ channels in epithelia. Induces apoptosis.
Product Specification
Alternative Name: BFA, Ascotoxin, Decumbin
Formula: C16H24O4
MW: 280.4
Purity: ≥98% (TLC)
Appearance: White to off-white solid.
CAS: 20350-15-6
MI: 14: 1369
Source/Host: Isolated from Eupenicillium brefeldianum.
Solubility: Soluble in DMSO (20mg/ml), 100% ethanol (5mg/ml), methanol, acetone or ethyl acetate (1mg/ml).
Shipping: AMBIENT
Long Term Storage: -20°C
Hazard: HARMFUL.