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Replaces Prod. #: ALX-162-001
Cell permeable, amphiphilic, mast cell degranulating tetradecapeptide. Stimulates glycogenolysis and phospholipase D2 (PLD2) activity. Alters G-proteins in brain membranes. Directly activates G proteins by a mechanism analogous to that of G protein-coupled receptors. Acts preferentially on Gi and Go rather than Gs. Stimulates exocytosis and phosphoinositide breakdown in a variety of cells. Inhibits calmodulin, and activates PLA2. Acts as a mitogen in Swiss 3T3 cells and stimulates pertussis toxin-sensitive arachidonate release without phosphoinositide breakdown.
Product Specification
Formula: C70H131N19O15
MW: 1478.9
Purity: ≥98% (HPLC)
Sequence: H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2
Formulation: Lyophilized.
CAS: 72093-21-1
Source/Host: Synthetic. Originally isolated from wasp venom (Vespula lewisii).
Solubility: Soluble in water (1 mg/ml) or 100% ethanol.
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C