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BML-PW0595-0100 100 µl
BML-PW0595-0025 25 µl
Product Specification
Alternative Name: Htt, HD Protein
Purity Detail: Purified by salt precipitation.
Formulation: Liquid. In PBS containing 0.01% sodium azide. 
Immunogen: Synthetic peptide corresponding to aa 2-17 of human huntingtin.
Source/Host: From rabbit.
Specificity: Recognizes human huntingtin (irrespective of SUMOylation status).
Application: Western Blot (1:1'000)
Optimal conditions must be determined individually for each application.
Shipping: SHIPPED ON BLUE ICE
Short Term Storage: +4°C
Long Term Storage: -20°C
Use/Stability: Stable for at least 1 year after receipt when stored at -20°C. Dilute with PBS, pH 7.2-7.4, containing 1% normal goat serum (if a goat anti-rabbit IgG linker antibody is to be used). Store diluted antibody at +4°C, do not freeze and use within 1 month.
Handling: After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.  
Miscellaneous/General: Huntington’s disease (HD) is a neurodegenerative disorder caused by an expanding polyglutamine repeat in the huntingtin gene (>35 repeats results in HD onset). Expansion of this polyglutamine repeat may induce a toxic gain of function perhaps through interactions with other cellular proteins. The huntingtin protein is thought to be necessary for neuronal survival and is involved in synaptic vesicle trafficking, microtubule binding and may also have a role in apoptosis. SUMO modification at the N-terminus of the huntingtin protein is also believed to play a role in the neurodegenerative process.