BML-PW9775-0100 100 µl
BML-PW9775-0025 25 µl
NEDP1, a human NEDD8-specific protease, is highly conserved throughout evolution and equivalent proteins are present in yeast, plants, insects and mammals. NEDP1 appears to be specific for NEDD8 as neither ubiquitin nor SUMO bearing COOH-terminal extensions are utilized as substrates. Inhibition studies and mutagenesis indicate that NEDP1 is a cysteine protease with sequence similarities to SUMO-specific proteases and the class of viral proteases typified by the adenovirus protease. In vivo NEDP1 deconjugates NEDD8 from a wide variety of substrates including the cullin component of SCF complexes.
Thus NEDP1 is likely to play an important role in ubiquitin-mediated proteolysis by controlling the activity of SCF complexes1.
Product Specification
Alternative Name: NEDD8-specific protease 1, SENP8, Sentrin-specific protease 8, Deneddylase 1
Immunogen: Recombinant full length human NEDP1.
Source/Host: From sheep.
Specificity: Recognizes human NEDP1.
Application: Western Blot
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C 
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