| 生化机理 |
Temozolomide is an antitumor, antiangiogenic compound that has been shown to work by alkylating DNA, typically through addition of a methyl group to guanine in genomic DNA. The efficacy of this compound is dependent on its ability to methylate the DNA, thus triggering apoptosis; however, some cells are able to repair this damage via the enzymes O-6-methylguanine-DNA methyltransferase (MGMT). As a enzyme. Research has also been conducted to determine whether MGMT inhibitors such as O-6-benzylguanine might help to increase the efficacy of temozolomide. Furthermore, temozolomide has been implicated in causing arrest at the G2/M cell cycle checkpoint, which might also play a role in its cytotoxicity. |
| 别名 |
替莫唑胺;3,4-二氢-3-甲基-4-氧代咪唑并[5,1-d]-1,2,3,5-四嗪-8-甲酰胺;8-氨基甲酰基-3-甲基咪唑[5,1-d]并-1,2,3,5-四氮嗪-4-(3H)-酮;4-甲基-5-氧代-2,3,4,6,8-五氮杂双环[4.3.0]壬-2,7,9-三烯-9-甲酰胺; 3-甲基-4-氧代-8-咪唑并[5,1-d][1,2,3,5]四嗪甲酰胺;NSC 362856; CCRG 81045; TZM;3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide |
产品描述
