溶解性 |
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存贮条件 | 储存温度-20°C |
备注 | Thiazovivin (Tzv) is a novel ROCK inhibitor with IC50 of 0.5 μM, promotes hESC survival after single-cell dissociation. |
生化机理 |
Thiazovivin is a compound which dramatically improves the survival of hESCs upon trypsinization. In combination with ALK5 (TGFβ receptor) inhibitor SB-431542 and MEK inhibitor PD-0325901, thiazovivin promotes the transformation of fibroblasts into stem cells with a 200-fold efficiency over the classic method.Thiazovivin is useful for reprogramming human somatic cells |
别名 | N-benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide;N-benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide |