Olaparib (AZD2281, Ku-0059436):原理_价格_参数_使用方法-耗材谱::分析测试百科网

溶解性	Soluble in DMSO (33 mg/mL), ethanol (1.7 mg/mL), and water (<1 mg/mL) at 25 °C.
存贮条件	储存温度-20°C

应用	A potent inhibitor of PARP
产品介绍	Olaparib (AZD2281, Ku-0059436)是一种选择性的PARP1/2抑制剂，IC50为5 nM/1 nM，比对Tankyrase-1的作用强300倍。
备注	Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM, 300-times less effective against tankyrase-1. Phase 1/2.
生化机理	Olaparib is a potent inhibitor of both PARP-1 and PARP-2, with IC50 = 5 nM and 1 nM, respectively. Olaparib is strongly sensitive to KB2P cells due to suppression of base excision repair by PARP inhibition, which may result in the conversion of single-strand breaks to double-strand breaks during DNA replication, thus activating BRCA2-dependent recombination pathways
别名	KU-0059436;奥拉帕尼; 1-(环丙甲酰基)-4-[5-[(3,4-二氢-4-氧代-1-酞嗪基)甲基]-2-氟苯甲酰]哌嗪;AZD2281;KU-0059436;KU0059436;AZD-2281;KU0059436;AZD 2281;1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine

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