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产品描述
| 熔点 | 162-164°C |
| 溶解性 | DMSO ≥55mg/mL Water <1.2mg/mL Ethanol ≥3.6mg/mL |
| 存贮条件 | 储存温度-20°C |
| 应用 | A DNA intercalator and topoisomerase II inhibitor |
| 产品介绍 | Amonafide(AS1413)能通过拓扑异构酶II介导的反应产生蛋白相关的DNA链断裂，但不产生拓扑异构酶I介导的DNA断裂。 |
| 备注 | Amonafide produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. Phase 3. |
| 生化机理 | Amonafide is a DNA intercalator and Topo II (topoisomerase II) inhibitor for the treatment of neoplastic diseases. Antitumor agent. |
| 别名 | AS1413, 氨萘非特; 5-氨基-2-[2-(二甲基氨基)乙基]-1H-苯并[de]异喹啉-1,3(2H)-二酮;Xanafide; Quinamed;Nafidimide;5-Amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione |
