[S(R)]-N-[(1R)-1-[2-(二苯基膦)苯基]乙基]-2-叔丁基亚磺酰胺
[S(R)]-N-[(S)-[2-(二环己基膦)苯基](5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基)甲基]-2-叔丁基亚磺酰胺
[S(R)]-N-[(S)-[3,5-二叔丁基-4-甲氧基苯基][2-(二环己基膦)苯基]甲基]-2-叔丁基亚磺酰胺
[S(R)]-N-[(1S)-1-[2-(二环己基膦)苯基]乙基]-N-甲基-2-叔丁基亚磺酰胺
[S(R)]-N-[(1S)-1-[2-(9-蒽基)苯基]-2-(二苯基膦)乙基]-N-甲基-2-叔丁基亚磺酰胺
[S(R)]-N-[(S)-[2-(二苯基膦)苯基]苯基甲基]-N-甲基-2-叔丁基亚磺酰胺
溶解性 | DMSO 79mg/mL; Water <1 mg/mL; Ethanol 31 mg/mL |
存贮条件 | 储存温度-20°C |
产品介绍 | AZD2461是新型PARP抑制剂,能够避免由Pgp介导的olaparib抗性。 |
备注 | AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib. Phase 1. |
生化机理 | AZD2461 has an 80-fold increased Mdr1b expression on Olaparib-resistant KB1P tumor T6-28, without inhibition of Pgp. AZD2461 induces loss of 53BP1 expression in mice with KB1P tumors with short-term treatment. Long-term AZD2461 treatment is well tolerated and doubled the median relapse-free survival. |
别名 | 4-(4-氟-3-((4-甲氧基哌啶-1-基)羰基)苄基)酞嗪-1(2H)-酮;AZD2461;AZD 2461;4-(4-fluoro-3-((4-methoxypiperidin-1-yl)carbonyl)benzyl)phthalazin-1(2h)-one |