产品描述
| 溶解性 | Soluble in water (>500 mg/ml), PBS (pH 7.2) (≥10 mg/ml), ethanol (≥20 mg/ml), DMSO (100 mM), and DMF (≥20 mg/ml). |
| 应用 | A specific antagonist of the AT1 receptor with significant downstream effects. |
| 产品介绍 | Losartan potassium is a new drug used for hypertension. It is nonpeptide angiotensin II (AII) receptor antagonist. Losartan potassium is nonpeptide angiotensin II (AII) receptor antagonist and is orally active. It belongs to a new class of drugs introduced for clinical trials to treat hypertension. |
| 备注 | Losartan is an angiotensin II receptor antagonist, competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM. |
| 生化机理 | Losartan Potassium is a specific antagonist of the angiotensin II receptor subtype AT1. Antagonism of the AT1 receptor and interference of association between AT1 and angiotensin II produces vasodilation and reduction of hypertension. This antagonism has other downstream effects, including a correlated antagonism of the thromboxane A2 receptor, inhibition of platelet aggregation, and induction of peroxisome proliferator-actived receptor gamma (PPARγ) activity. |
| 别名 | 2-丁基-4-氯-1-{[2′-(1H-四唑-5-基)(1,1′-联苯)-4-基]甲基}-1H-咪唑-5-甲醇 单钾盐; 2-丁基-4-氯-5-(羟甲基)-[[2'-(1H-四氮唑-5-基)联苯-4-基]甲基]咪唑钾; 洛沙坦钾;氯沙坦钾 ;potassium[2-butyl-5-chloro-3-[[4-[2-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol; DuP-753 potassium; Cozaar potassium |
