产品描述
| 溶解性 | DMSO ≥12mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL |
| 存贮条件 | 储存温度-20°C |
| 应用 | A specific ETAR antagonist |
| 产品介绍 | Zibotentan (ZD4054)是口服活性的内皮素A（ETA）受体特异性拮抗剂，IC50为21 nM。 |
| 生化机理 | Zibotentan (ZD4054) is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM). Zibotentan is capable of inhibiting or reducing the multitude of effects that are evoked by ET-1 activation of the ETA receptor and which promote tumor survival, growth and progression. Zibotentan (ZD4054) treatment produced significant inhibition of tumor growth in ovarian and breast xenografts. |
| 别名 | ZD4054;ZD-4054;ZD 4054; N-(3-甲氧基-5-甲基-2-吡嗪基)-2-(4-(1,3,4-恶二唑-2-基)苯基)-3-吡啶磺酰胺;;ZD4054;ZD-4054;ZD 4054; n-(3-methoxy-5-methyl-2-pyrazinyl)-2-(4-(1,3,4-oxadiazol-2-yl)phenyl)-3-pyridinesulfonamide |
