AM1241

AM1241

产品参数

货号 规格 操作
A129838-10mg 咨询
A129838-1mg 咨询
A129838-25mg 咨询
A129838-50mg 咨询
A129838-5mg 咨询
更多货号咨询>>
关闭

服务地域:全国

属性:产地:上海; 品牌:阿拉丁 ;货期:现货

上海阿拉丁生化科技股份有限公司

高级会员 高级会员
推荐产品推荐产品
产品描述产品描述
  • 分子式 C22H22IN3O3
  • 分子量503.33
  • Beilstein号
  • EC号 MFCD11045986
  • MDL号
  • PubChem编号

属性

溶解性
  • DMSO 101 mg/mL
  • Water <1 mg/mL
  • Ethanol <1 mg/mL
  • 存贮条件 储存温度-20°C

    描述

    应用 (R,S)-AM1241, a selective CB2 cannabinoid receptor agonist, has been used to study neuropathic pain in animal models
    产品介绍 AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.
    备注 AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.
    生化机理 AM-1241 is a protean agonist of CB2 based on the different effect observed in various assays (calcium influx, extracellular signal-regulated kinase (ERK) phosphorylatin and cAMP measurement)) and on the switch from neutral antagonism to agonism in the cAMP assay when forskolin concentration is lowered. In [3H]CP 55,940 competition binding assays, AM-1241 displays high affinity at the human CB2 receptor with a Ki value of about 7 nM, whereas its affinity at the human CB1 receptor is more than 80-fold weaker, using membrane preparations from stable HEK and CHO cell lines expressing the recombinant human CB2 and CB1 receptors, respectively.
    别名 ((R,S)-AM 1241; (R,S)-3-(2-碘-5-硝基苯甲酰)-1-(1-甲基-2-哌啶甲基)-1H-吲哚;(R,S)-AM1241; (R,S)-3-(2-Iodo-5-nitrobenzoyl)-1-(1-methyl-2-piperidinylmethyl)-1H-indole
    AI问答 配套的仪器设备? X
    店铺 店铺 咨询留言 咨询留言 热线电话 热线电话