产品描述
| 溶解性 | 25°C: DMSO |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | Reparixin(DF 1681Y)是CXCL8受体抑制剂，同时还能抑制CXCR1和CXCR2的活性，能减低多种损伤模型中的炎症反应。 |
| 生化机理 | The efficacy of RPX (tested in a wide range of concentrations (1-1000 nM)) was lower in cells expressing Ile43Val CXCR1 mutant (IC50 values of 0.0056 and 0.08 uM for CXCR1 weight and CXCR1 Ile43Val, respectively). Treatment with reparixin significantly counteracts secondary degeneration by reducing oligodendrocyte apoptosis, migration to the injury site of neutrophils and ED-1-positive cells。 |
| 别名 | DF 1681Y;Repertaxin；(R)-(-)-N-2-[(4-Isobutylphenyl)propionyl]methanesulfonamide; |
