熔点 | 240-243 °C |
溶解性 | Soluble in water (<1 mg/ml) at 25 °C, DMSO (127 mg/ml ) at 25 °C, and ethanol (<1 mg/ml ) at 25 °C. |
存贮条件 | 储存温度-20°C |
应用 | An inhibitor of Flk-1 (VEGFR), PDGFR and Raf kinases. |
产品介绍 | Sorafenib Tosylate是酪氨酸激酶(VEGFR和PDGFR)和RAF/MEK/ERK级联抑制剂,同时作用于Raf-1,wtBRAF和V599EBRAF,IC50分别为6 nM, 22 nM和38 nM。 |
备注 | Sorafenib Tosylate (Bay 43-9006) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively. |
生化机理 | Sorafenib Tosylate is an inhibitor of c-Kit, Flk-1, Flt-3/Flk-2, Flt-4, PDGFR-β, Raf-1 and Raf-B |
别名 | 甲苯磺酸索拉非尼; 4-{4-[3-(4-氯-3-三氟甲基苯基)酰脲]苯氧基}吡啶-2-甲酰胺对甲苯磺酸盐;Nexavar; Bay 43-9006; Sorafenib |