熔点 | 283° C |
溶解性 | DMSO ≥42mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL |
存贮条件 | 储存温度-20°C |
应用 | A potent, selective and reversible inhibitor of JNK1, JNK-2, and JNK-3 |
产品介绍 | SP600125是泛JNK抑制剂,对JNK1,JNK2和JNK3的IC50分别为40 nM,40 nM和90 nM,比对MKK4和MKK3,MKK6,PKB,PKCα的抑制性高10倍和超过25倍。 |
备注 | SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selec |
生化机理 |
SP600125 is selective inhibitor of c-Jun N-terminal kinase (JNK). SP600125 competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes (IC50 > 10 μM). Active in vivo. Shown to have reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis. |
别名 | 吡唑蒽酮; 蒽并[1,9-cd]吡唑-6(2H)-酮;SP 600125;SP-600125;1,9-Pyrazoloanthrone;Anthra[1,9-cd]pyrazol-6(2H)-one;JNK Inhibitor II |