SCH772984:原理_价格_参数_使用方法-耗材谱::分析测试百科网

溶解性	DMSO mg/mL Water mg/mL Ethanol mg/mL
存贮条件	储存温度-20°C

备注	SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.
生化机理	Description: IC50 Value: N/A SCH772984 is a novel and selective inhibitor of ERK1/2 which displays behaviors of both type I and type II kinase inhibitors. SCH772984 has nanomolar cellular potency on tumor cells with mutations in BRAF, NRAS, or KRAS and induces tumor regressions in xenograft models at tolerated doses. SCH772984 effectively inhibited MAPK signaling and cell proliferation in BRAF or MEK inhibitor resistant models as well as in tumor cells resistant to concurrent treatment with BRAF and MEK inhibitors [1]. in vitro: N/A in vivo: N/A Clinical trial: N/A
别名	3-Pyrrolidinecarboxamide, 1-[2-oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-(3-phenyl-1H-indazol-5-yl)-, (3R)-;3-Pyrrolidinecarboxamide, 1-[2-oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-(3-phenyl-1H-indazol-5-yl)-, (3R)-

上海阿拉丁生化科技股份有限公司