产品描述
| 熔点 | 240.48 °C |
| 溶解性 | Soluble in DMSO (36 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C). |
| 存贮条件 | 储存温度 2-8°C |
| 应用 | A selective and reversible inhibitor of fatty acid amide hydrolase (FAAH). |
| 产品介绍 | JNJ-1661010是一种有效的，选择性的FAAH抑制剂，IC50分别为10 nM(大鼠)和12 nM (人类)，作用于FAAH-1比作用于FAAH-2选择性高100倍以上。 |
| 备注 | JNJ-1661010 is a potent and selective FAAH inhibitor with IC50 of 10 nM (rat) and 12 nM (human), exhibits >100-fold selectivity for FAAH-1 when compared to FAAH-2. |
| 生化机理 | JNJ 1661010 is a selective and reversible inhibitor of fatty acid amide hydrolase (FAAH) (IC50 = 12nM). JNJ 1661010 can also cross the blood-brain barrier. |
| 别名 | N-苯基-4-(3-苯基-1,2,4-噻二唑-5-基)-1-哌嗪甲酰胺;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide |
