产品描述
| 熔点 | 175°C |
| 敏感性 | 对空气敏感 ;对光线敏感 ;对热敏感 |
| 溶解性 | Soluble in chloroform (50 mg/ml), DMSO (60 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (25 mg/ml), and ether (sparingly). |
| 存贮条件 | 储存温度 -20°C;充氩保存 |
| 应用 |
A vitamin A analog that inhibits cell proliferation. 13-cis-Retinoic acid has been used: · as a component of fresh media for LA-N-5 differentiation · to treat medulloblastoma cells for cell differentiation · to treat spheroids for generating time-lapse videos · to examine its head- deforming activity under light and dark conditions in Xenopus laevis |
| 生化机理 | 13- 顺 -维甲酸 (RA) 具有抗炎和抗肿瘤操作。RA 的操作是通过 RAR-β 介导的和 RAR-α受体。RA 可减弱细胞因子刺激的小鼠系膜细胞 iNOS 的表达和活性。它诱导线粒体膜通透性转换，观察为肿胀和膜电位降低，并通过细胞凋亡途径刺激细胞色素 c 的释放牵连机制。这些活动被 EGTA 和环孢霉素 A 逆转。RA 也部分通过增加转录增加 MMP-1 蛋白表达。 |
| 别名 | 异维 A 酸;13-顺-视黄酸;保肤灵;3,7-二甲基-9-(2,6,6-三甲基环己烯)-2-顺,4-反,6-反,8-反式壬四烯酸;13-cis-Retinoic acid;(2Z,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid |
