产品描述
| 熔点 | 228-232 °C |
| 溶解性 | Soluble in water (<1 mg/ml at 25 °C), DMSO (2 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), DMF (10 mg/ml), and methanol. |
| 存贮条件 | 储存温度-20°C |
| 应用 | A selective serotonin antagonist. |
| 产品介绍 | Ketanserin 是一种特异性的5-HT2A 5-羟色胺受体拮抗剂，作用于大鼠和人5-HT2A，Ki为2.5 nM。 |
| 备注 | Ketanserin (Vulketan Gel) is specific 5-HT2A serotonin receptor antagonist with a Ki of 2.5 nM for rat and human 5-HT2A. |
| 生化机理 | Ketanserin is reported to have a high affinity for multiple G protein-coupled receptors, such as serotonin receptors. Ketanserin is a selective serotonin 5-HT2/5-HT1C antagonist. It has been used to distinguish between 5-HT1D and 5-HT1B receptor subtypes. Additional studies have noted that Ketanserin is able to differentiate between recombinant human forms of these receptors with a higher affinity for 5-HT1Dα receptors compared to 5-HT1Dβ receptors. |
| 别名 | 酮色林; 酮舍林; 凯坦色林; 凯他色林; 3-[2-[4-(4-氟苯甲酰)-1-哌啶基]乙基]-2,4[1H,3H]-喹唑二酮;R-49945;Perketan;R-49945;3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4(1H,3H)-quinazolinedione |
