产品描述
| 沸点 | ~836.0 °C at 760 mmHg |
| 熔点 | 328.47 °C |
| 溶解性 | DMSO |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.4000 |
| 应用 | A potent γ-secretase inhibitor |
| 产品介绍 | LY411575是γ-secretase抑制剂，基于膜和细胞的实验IC50分别为0.078 nM/0.082 nM，还能抑制Notch clevage，IC50为0.39 nM。 |
| 生化机理 | LY-411575 is potent, cell permeable and selective γ-secretase inhibitor that reduces Aβ/42 after acute or chronic treatment, and blocks Notch activation. Studies (Cancer Cell) have shown that treatment with LSN-411575 arrests KrasG12V-driven NSCLCs in association with inhibition of HES1 expression and ERK phosphorylation. |
| 别名 | LY411575; LY 411575; (aS)-N-[(1S)-2-[[(7S)-6,7-二氢-5-甲基-6-氧代-5H-二苯并[b,d]氮杂卓-7-基]氨基]-1-甲基-2-氧代乙基]-3,5-二氟-alpha-羟基苯乙酰胺;LY411575; LY 411575;(aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide; N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide |
